Ultrafast and accurate sequence alignment and clustering of viral genomes

Speaker(s)

Sebastian Deorowicz

Affiliation

Silesian University of Technology

Language of the talk

English

Date

March 26, 2025, 10:15 a.m.

Room

room 3250

Seminar

Seminar Computational Biology and Bioinformatics

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Viromics produces millions of viral genomes and fragments annually, overwhelming traditional sequence comparison methods. We introduce Vclust, an approach that determines average nucleotide identity by Lempel-Ziv parsing and clusters viral genomes with thresholds endorsed by authoritative viral genomics and taxonomy consortia. Vclust demonstrates superior accuracy and efficiency compared to existing tools, clustering millions of genomes in a few hours on a mid-range workstation.

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