Insulin/IGF/Relaxin family

Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin.
All are secreted regulatory hormones. Disulfide rich, all-alpha fold.
Alignment includes B chain, linker (which is processed out of the final product), and A chain.




>PF000490010    IGF2_ONCMY
  METQKRHEYHSVCHTCRRTENTRMKVKMMSSSNRVLVIALALTLYIVEVASAETLCGGELVDALQFVCED
  RGFYFSRPTSRSNSRRSQNRGIVEECCFRSCDLNLLEQYCAKPAKSERDVSATSLQIIPMVPTIKQDVPR
  KHVTVKYSKYEAWQRKAAQRLRRGVPAILRARKFRRQAVKIKAQEQAMFHRPLITLPSKLPPVLPPTDNY
  VSHN

>PF000490027  RELX_PIG
  MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAE
  TMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDK
  SLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC



BLAST alignment is only 13 residues long, while CTX-BLAST output  (149 residues) covers the whole structural motiv.


          ********************   BLAST OUTPUT *********************
Query= PF000490010
         (214 letters)

>PF000490027
          Length = 182

Query: 56 CGGELVDALQFVC 68
          CG ELV+     C
Sbjct: 34 CGRELVRLWVEIC 46

        ********************   CTX-BLAST OUTPUT *********************
Query= PF000490010
         (214 letters)

Query: 56  CGGELVDALQFVCEDRGFYFSRP------TSRSNSRRSQNRGIVEECCFRSCDLNLLEQY 109
           CG ELV  +   C    +  +                +    I ++       L  +
Sbjct: 34  CGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAETMPSSITKDAEILKMMLEFVPNL 93

Query: 110 CA---KPAKSERDVSATSLQIIPMVPTIKQDVPRKHVTVKYSKYEAWQRKAAQRLRRGVPA 167
                 K  SER  S   LQ   +       +   +        EA  +   +    G+
Sbjct: 94  PQELKATLSERQPSLRELQQ--SASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLDK 152

Query: 168 ILRARKFRRQAVKIKAQEQAMFHRPLITL 196
             R ++  R  +  K  + + +      L    
Sbjct: 153 HSRKKRLFRMTLSEKCCQVGCIRKDIARL 181