Rhabdovirus spike glycoprotein


Frequently abbreviated to G protein. The glycoprotein spike is made up of a trimer of G proteins.
Channel formed by glycoprotein spike is thought to function in a similar manner to Influenza G protein structure
virus M2 protein channel, thus allowing a signal to pass across the viral membrane to signal
for viral uncoating.







>PF009740001
  MALLCFETERNSQRPTKTMDTTITTPLILILITCGANSQTVKPDTASESDQPTWSNPLFTYPEGCTLDKL
  SKVNASQLRCPRIFDDENRGLIAYPTSIRSLSVGNDLGDIHTQGNHIHKVLYRTICSTGFFGGQTIEKA
  VEMKLSTKEAGAYDTTTAAALYFPAPRCQWYTDNVQNDLIFYYTTQKSVLRDPYTRDFLDSDFIGGKCTK
  SPCQTHWSNVVWMGDAGIPACDSSQEIKGHLFVDKISNRVVKATSYGHHPWGLHQACMIEFCGKQWIRTD
  LGDLISVEYNSGAEILSFPKCEDKTVGMRGNLDDFAYLDDLVKASESREECLEAHAEIISTNSVTPYLLS
  KFRSPHPGINDVYAMHKGSIYHGMCMTVAVDEVSKDRTTYRAHRATSFTKWERPFGDEWEGFHGLHGNNT
  TIIPDLEKYVAQYKTSMMEPMSIKSVPHPSILALYNETDVSGISIRKLDSFDLQSLHWSFWPTISALGGI
  PFALLLAVAACCCWSGRPPTPSASQSIPMYHLANRS


 >PF009740005
  MDLFPILVVVLMTDTVLGKFQIVFPDQNELEWRPVVGDSRHCPQSSEMQFDGSRSQTILTGKAPVGITPS
  KSDGFICHAAKWVTTCDFRWYGPKYITHSIHHLRPTTSDCETALQRYKDGSLINLGFPPESCGYATVTDS
  EAMLVQVTPHHVGVDDYRGHWIDPLFPGGECSTNFCDTVHNSSVWIPKSQKTDICAQSFKNIKMTASYPS
  EGALVSDRFAFHSAYHPNMPGSTVCIMDFCEQKGLRFTNGEWMGLNVEQSIREKKISAIFPNCVAGTEIR
  ATLESEGARTLTWETQRMLDYSLCQNTWDKVSRKEPLSPLDLSYLSPRAPGKGMAYTVINGTLHSAHAKY
  IRTWIDYGEMKEIKGGRGEYSKAPELLWSQWFDFGPFKIGPNGLLHTGKTFKFPLYLIGAGIIDEDLHEL
  DEAAPIDHPQMPDAKSVLPEDEEIFFGDTGVSKNPIELIQGWFSNWRESVMAIVGIVLLIVVTFLAIKTV
  RVLNCLWRPRKKRIVRQEVDVESRLNHFEMRGFPEYVKR

 

Both sequences give best structural hit to CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION

BLAST alignment is only 198 residues long, while CTX-BLAST output  (353 residues) covers the whole structural motiv.

********************   BLAST OUTPUT *********************

>PF009740005
          Length = 529

 Score = 38.1 bits (87), Expect = 8e-007
 Identities = 43/198 (21%), Positives = 83/198 (41%), Gaps = 16/198 (8%)

Query: 118 HKVLYRTICSTGFFGGQTIEKALVEMKLSTKEAGA----YDTTTAAALYFPAPRCQWYTD 173
           H   + T C   ++G + I  ++  ++ +T +       Y   +   L FP   C  Y 
Sbjct: 78  HAAKWVTTCDFRWYGPKYITHSIHHLRPTTSDCETALQRYKDGSLINLGFPPESCG-YAT 136

Query: 174 NVQNDLIFYYTTQKSVLRDPYTRDFLDSDFIGGKCTKSPCQTHWSNVVWMGDAGIP--AC 231
              ++ +    T   V  D Y   ++D  F GG+C+ + C T  ++ VW+  +      
Sbjct: 137 VTDSEAMLVQVTPHHVGVDDYRGHWIDPLFPGGECSTNFCDTVHNSSVWIPKSQKTDICA 196

Query: 232 DSSQEIKGHLFVDK----ISNRVVKATSYGHHPWGLHQACMIEFCGKQWIRTDLGDL--I 285
            S + IK           +S+R    ++Y H        C+++FC ++ +R   G+   +
Sbjct: 197 QSFKNIKMTASYPSEGALVSDRFAFHSAY-HPNMPGSTVCIMDFCEQKGLRFTNGEWMGL 255

Query: 286 SVEYNSGAEILS--FPKC 301
           +VE +   + +S  FP C
Sbjct: 256 NVEQSIREKKISAIFPNC 273


********************   CTX-BLAST OUTPUT *********************


>PF009740005
          Length = 529

 Score = 48.8 bits (82), Expect = 5e-010
 Identities = 56/353 (15%), Positives = 111/353 (31%), Gaps = 25/353 (7%)

Query: 111 HTQGNHIHKVLYRTICSTGFFGGQTIEKALVEMKLSTKEA----GAYDTTTAAALYFPAP 166
            + G   H   + T C   ++G + I  ++  ++ +T +       Y   +   L FP 
Sbjct: 71  KSDGFICHAAKWVTTCDFRWYGPKYITHSIHHLRPTTSDCETALQRYKDGSLINLGFPPE 130

Query: 167 RCQWYTDNVQNDLIFYYTTQKSVLRDPYTRDFLDSDFIGGKCTKSPCQTHWSNVVWMGDA 226
            C  Y     ++ +    T   V  D Y   ++D  F GG+C+ + C T  ++ VW+  +
Sbjct: 131 SC-GYATVTDSEAMLVQVTPHHVGVDDYRGHWIDPLFPGGECSTNFCDTVHNSSVWIPKS 189

Query: 227 GIPACDSSQEIKGHLFVDKISNRVVKATSYGHHPWGLH------QACMIEFCGKQWIRTD 280
                  +Q  K         +     +         H        C+++FC ++ +R 
Sbjct: 190 Q-KTDICAQSFKNIKMTASYPSEGALVSDRFAFHSAYHPNMPGSTVCIMDFCEQKGLRFT 248

Query: 281 LGDLISVEYNSGAEILSFPKCEDKTVGMRGNLDDFAYLDDLVKASESREE-----CLEAH 335
            G+ + +                  V                   E++       C   
Sbjct: 249 NGEWMGLNVEQSIREKKISAIFPNCVAGTEIRATLESEGARTLTWETQRMLDYSLCQNTW 308

Query: 336 AEIISTNSVTPYLLSKFRSPHPGINDVYAMHKGSIYHGMCMTVA-------VDEVSKDRT 388
            ++     ++P  LS      PG    Y +  G+++      +        + E+   R
Sbjct: 309 DKVSRKEPLSPLDLSYLSPRAPGKGMAYTVINGTLHSAHAKYIRTWIDYGEMKEIKGGRG 368

Query: 389 TYRAHRATSFTKWERPFGDEWEGFHGLHGNNTTIIPDLEKYVAQYKTSMMEPM 441
            Y       +++W   FG    G +GL     T    L    A      +  +
Sbjct: 369 EYSKAPELLWSQW-FDFGPFKIGPNGLLHTGKTFKFPLYLIGAGIIDEDLHEL 420